Bisset, Alexander A., Dishington, Allan, Jones, Teyrnon C., Clarkson, Guy J. and Wills, Martin (2014) Synthesis and reduction reactions of pyridones and 5-acyl-2-methoxypyridines. Tetrahedron, 70 (40). pp. 7207-7220. doi:10.1016/j.tet.2014.06.046 ISSN 0040-4020 .
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Abstract
The synthesis of a series of pyridones, from their 2-hydroxypyridine or 2-methoxypyridine precursors, is described, along with studies into their reductions to saturated heterocycles. A number of 5-acylpyridones were prepared and were evaluated as substrates for asymmetric transfer hydrogenation prior to conversion to saturated heterocycles. The enantioselective reduction of 5-acetyl-1-benzylpyrimidine-2,4(1H,3H)-dione is also described.
| Item Type: | Journal Article |
|---|---|
| Subjects: | Q Science > QD Chemistry |
| Divisions: | Faculty of Science, Engineering and Medicine > Science > Chemistry |
| Library of Congress Subject Headings (LCSH): | Organic compounds -- Synthesis, Hydroxypyridones -- Sythesis |
| Journal or Publication Title: | Tetrahedron |
| Publisher: | Pergamon |
| ISSN: | 0040-4020 |
| Official Date: | October 2014 |
| Dates: | Date Event October 2014 Published 19 June 2014 Available 13 June 2014 Accepted 22 April 2014 Submitted |
| Volume: | 70 |
| Number: | 40 |
| Number of Pages: | 14 |
| Page Range: | pp. 7207-7220 |
| DOI: | 10.1016/j.tet.2014.06.046 |
| Status: | Peer Reviewed |
| Publication Status: | Published |
| Access rights to Published version: | Restricted or Subscription Access |
| Date of first compliant deposit: | 28 December 2015 |
| Date of first compliant Open Access: | 28 December 2015 |
| Funder: | Engineering and Physical Sciences Research Council (EPSRC), AstraZeneca (Firm) |
| Related URLs: | |
| URI: | https://wrap.warwick.ac.uk/63849/ |
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